What is Apokyn
is used by injection, as needed, only to treat loss of control of body
movements in people with advanced Parkinson?s disease (PD). This
condition is also called hypomobility or ?off? episodes. An
"off" episode may include symptoms such as muscle stiffness,
slow movements, and difficulty starting movements. Apokyn may improve your
ability to control your movements when it is used during an ?off?
episode. This may help you walk, talk, or move around easier. Apokyn is
not used to prevent ?off? episodes. Apokyn does not take the place of
your other medicines for PD.
Who should not
Do not take Apokyn if you are:
to Apokyn or to any of its ingredients. Apokyn
contains a sulfite called metabisulfite. Sulfites
can cause severe, life-threatening allergic reactions in some people,
especially in people with asthma.
treated with certain drugs to treat nausea and vomiting or irritable
bowel syndrome. These medications (including, for example, ondansetron,
granisetron, dolasetron, palonosetron, and alosetron) are called 5HT3 antagonists
or blockers. People taking this type of drug together with apomorphine
have had severely low blood pressure and lost consciousness or
Warning(s) with Apokyn:
Apokyn should be injected just under the skin
(subcutaneously), and not into a vein.
Carefully read the Apokyn ?Instructions for Use" for
complete instructions on preparing and giving an injection of Apokyn.
Do not inject Apokyn unless you and your caregiver have been taught
the right way and both of you understand all the directions. Ask your
doctor or pharmacist if you have any questions.
Precautions with Apokyn:
not drink alcohol or take medicines that make you sleepy while you are
not drive a car, operate machinery, or do anything that might put you
at risk of getting
hurt until you know how
Apokyn affects you. Apokyn may cause dizziness or fainting. Do
not change your body position too fast. Get up slowly from
sitting or lying. Apokyn can lower your blood pressure and cause dizziness
What should I
tell my health care provider?
Tell your health care provider if you:
low blood pressure
allergic to sulfites or sulfa medicines
had a stroke or other brain problems
a mental problem called a major psychotic disorder
- are trying to become pregnant, are already pregnant, or are
your health care provider about all the medicines you take, including
prescription and non-prescription medicines, vitamins, and herbal
supplements. Especially tell
your health care provider if you take:
medicines to treat nausea,
vomiting, or irritable bowel syndrome including 5HT3 antagonists or blockers
such as ondansteron (Zofran®), granisteron (Kytril®), dolasteron (Anzemet®),
vasodilators and other medicines that lower blood pressure
medicines that make you sleepy
What are some
possible side effects of Apokyn? (This list is
NOT a complete list of side effects reported with Apokyn.
Your health care provider can discuss with you a more complete list
of side effects.)
Some common side effects with Apokyn include:
problems (shortness of breath, fast heartbeat, chest pain)
nausea and vomiting
or falling asleep during the day
detailed information about Apokyn, ask your health care provider or