What is Avandia used for?
Avandia, in addition to
diet and exercise, improves blood sugar control in adults with type 2
(non-insulin-dependent) diabetes. Avandia
can be used alone or in combination with a sulfonylurea, metformin, or
insulin when diet, exercise, and one of these agents or diet,
exercise, plus Avandia alone are not enough to control blood sugar.
Who should not take Avandia?
Do not use Avandia for type I diabetes (juvenile diabetes)
or diabetic ketoacidosis.
If you have heart failure, fluid retention, or active liver
disease your health care provider will evaluate you to decide if Avandia
is right for you.
Reports of Patients? Experiences Since Avandia
have been reports of inflammation of the liver (hepatitis) and elevated
It has not been determined whether these events are directly
related to Avandia.
It is recommended that patients taking Avandia have their liver
enzymes monitored periodically.
General Precautions with Avandia:
Avandia is in the same class of drugs as Rezulin, which has
been associated with rare but serious liver injury, including liver
failure leading to transplant or death.
Because Avandia?s liver safety profile is not fully determined
yet, your doctor will do blood tests that evaluate your liver before
starting you on Avandia. These
blood tests should be repeated every two months for the first year, then
regularly after that.
Call your health care provider right away if you develop
nausea, vomiting, stomach pain, a feeling of tiredness or having no
energy, loss of appetite, dark urine, or jaundice (yellow coloring of eyes
and skin). These may be
symptoms of liver problems.
Patients who experience an unusually
rapid increase in weight or retain fluid (edema) or who develop shortness
of breath or other symptoms of heart failure while on Avandia should
immediately report these symptoms to their health care provider.
When taking Avandia with other oral diabetes medicines,
there is a risk of your blood sugar becoming dangerously low.
Ask your health care provider about symptoms of low blood sugar,
conditions that make low blood sugar more likely, and what to do if you
get it. Make sure to explain
to family members.
If you are a woman who has not reached menopause but have
not had menstrual periods, you may become pregnant unless you use an
effective method of birth control. Avandia,
like other drugs in this class, may cause insulin resistant women to start
Women should tell their doctor if they notice any changes in
their monthly menstrual cycle.
During periods of stress on the body, such as fever, trauma,
infection, or surgery, your medication requirements may change; contact
your health care provider promptly.
Managing your diabetes should
include diet control. Caloric
restriction, weight loss as needed,
and exercise are essential for the proper treatment of diabetes because
they help improve insulin sensitivity and the effectiveness of drug
should I tell my doctor or health care provider?
Tell you health care provider if you are trying
to become pregnant, are already pregnant, or are breast-feeding.
certain other medication may interact with Avandia, review all medications
that you are taking with your health care provider, including those that
you take without a prescription.
What are some possible side
effects of Avandia? (This list
is not a complete list
of side effects reported with Avandia. Your health care provider can
discuss with you a more complete list of side effects.)
cough or cold
inflammation of the sinuses
swelling or fluid retention
For more detailed information about Avandia, ask your health care